[2+2] Carbonylative cycloaddition of chiral imines to various allyl halides, under CO pressure, in the presence of Et3N, a catalytic amount of Pd(OAc)2 and PPh3 as ligand, are carried out. Separable diastereomeric mixtures of chiral alkenyl-b-lactams are isolated with good yields and high trans diastereoselections. Absolute configurations are assigned by X-ray measurements and 1H NMR spectroscopy.
[2+2 ] Carbonylative cycloaddition catalyzed by palladium: stereoselective synthesis of b-lactams.
TROISI, Luigino;DE VITIS, LUISELLA;GRANITO, Catia;PINDINELLI, EMANUELA
2004-01-01
Abstract
[2+2] Carbonylative cycloaddition of chiral imines to various allyl halides, under CO pressure, in the presence of Et3N, a catalytic amount of Pd(OAc)2 and PPh3 as ligand, are carried out. Separable diastereomeric mixtures of chiral alkenyl-b-lactams are isolated with good yields and high trans diastereoselections. Absolute configurations are assigned by X-ray measurements and 1H NMR spectroscopy.File in questo prodotto:
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