Lithiated (alfa-chloroalkyl)heterocycles, generated by deprotonation with LDA at -78 °C in THF, add to various enantiopure imines affording ‘one pot’ chiral heterosubstituted aziridines in a diastereoselective manner. Lithiated heterosubstituted aziridines, obtained by deprotonation of the corresponding aziridines with n-BuLi at -78 °C in THF, were trapped by electrophiles (D2O or CH3I) with high stereoselectivity.
Stereoselective Synthesis of Heterosubstituted Aziridines and their Functionalization
DE VITIS, LUISELLA;GRANITO, Catia;RONZINI, Ludovico;TROISI, Luigino;
2004-01-01
Abstract
Lithiated (alfa-chloroalkyl)heterocycles, generated by deprotonation with LDA at -78 °C in THF, add to various enantiopure imines affording ‘one pot’ chiral heterosubstituted aziridines in a diastereoselective manner. Lithiated heterosubstituted aziridines, obtained by deprotonation of the corresponding aziridines with n-BuLi at -78 °C in THF, were trapped by electrophiles (D2O or CH3I) with high stereoselectivity.File in questo prodotto:
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