Allyl halides of different structures, under CO pressure, in the presence of Et3N, a catalytic amount of Pd(OAc)2, and triphenylphosphane as ligand, undergo a [2+2] cycloaddition reaction with various imines. The reaction is highly regioand stereoselective: β-lactams are formed in good yields andwith trans diastereoselectivity in both the β-lactam ring and the vinylic moiety. New and important information is suggested regarding the known reaction mechanism.
The Stereoselective Synthesis of Alkenyl-β-lactams by Palladium-Catalyzed [2+2] Carbonylative Cycloaddition.
TROISI, Luigino;DE VITIS, LUISELLA;GRANITO, Catia;EPIFANI, Erbana
2004-01-01
Abstract
Allyl halides of different structures, under CO pressure, in the presence of Et3N, a catalytic amount of Pd(OAc)2, and triphenylphosphane as ligand, undergo a [2+2] cycloaddition reaction with various imines. The reaction is highly regioand stereoselective: β-lactams are formed in good yields andwith trans diastereoselectivity in both the β-lactam ring and the vinylic moiety. New and important information is suggested regarding the known reaction mechanism.File in questo prodotto:
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