This cross-sectional study investigated with two-dimensional gel electrophoresis coupled to MALDI-TOF and 15 MRI the relationship between PBMCs protein expression profile and whole brain atrophy in 16 unselected 16 RR-MS IFN-treated patients compared with 6 RRIFN-untreated and 12 matched healthy control subjects. 17 Grey/white matter fraction, T1/T2 lesion load and clinical variables were considered too. 18 Twenty six proteins showed significant differential expression among RR IFN-treated patients and control 19 samples. Four of these (IN35, GANAB, PP1B, SEPT2) resulted correlated with clinical and MRI findings in RR 20 IFN-treated MS patients. 21 Future clinical applications remain to be validated by other techniques and confirmed by a larger study.
PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: a pilot study on relation to clinical findings and brain atrophy
VERGARA, DANIELE;ACIERNO, Raffaele;GRECO, MARILENA;MAFFIA, Michele
2009-01-01
Abstract
This cross-sectional study investigated with two-dimensional gel electrophoresis coupled to MALDI-TOF and 15 MRI the relationship between PBMCs protein expression profile and whole brain atrophy in 16 unselected 16 RR-MS IFN-treated patients compared with 6 RRIFN-untreated and 12 matched healthy control subjects. 17 Grey/white matter fraction, T1/T2 lesion load and clinical variables were considered too. 18 Twenty six proteins showed significant differential expression among RR IFN-treated patients and control 19 samples. Four of these (IN35, GANAB, PP1B, SEPT2) resulted correlated with clinical and MRI findings in RR 20 IFN-treated MS patients. 21 Future clinical applications remain to be validated by other techniques and confirmed by a larger study.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
