Pt prodrugs: We synthesized new cationic complexes [PtCl(η2-C2H4)(R,R-chxn)]Cl (1) and [PtCl(η2-C2H4) (S,S-chxn)]Cl (2), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metabolites as those of oxaliplatin.
Water-soluble Organometallic Analogues of Oxaliplatin with Cytotoxic and Anticlonogenic Activity
BENEDETTI, MICHELEPrimo
;ANTONUCCI, DANIELA;MIGONI, DANILO;FANIZZI, Francesco Paolo
2010-01-01
Abstract
Pt prodrugs: We synthesized new cationic complexes [PtCl(η2-C2H4)(R,R-chxn)]Cl (1) and [PtCl(η2-C2H4) (S,S-chxn)]Cl (2), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metabolites as those of oxaliplatin.File in questo prodotto:
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