Aiming to contribute to the design of new antitumoral drugs, we synthesized new hydrophilic Pt(II) complexes of general formula [PtCl2(N,N0)] containing nitrogen bidentate amine–imine and di-imine ligands derived from glucose. Some chemical properties were discussed. The X-ray molecular structure of [PtCl2(a-D-glucopyranoside-methyl-6-deoxy-6(2-(methylimino)methyl)pyridine) (D) was reported. [Pt Cl2(b-D-glucopyranosylimine-N-(2-pyridinylmethyl))] (A), which is well-soluble both in organic solvents and in water, was tested for cytotoxicity.
Hydrophilic ligands derived from glucose: synthesis, characterization and invitro cytotoxic activity on cancer cells of Pt(II) complexes
FANIZZI, Francesco Paolo;MIGONI, DANILO;
2010-01-01
Abstract
Aiming to contribute to the design of new antitumoral drugs, we synthesized new hydrophilic Pt(II) complexes of general formula [PtCl2(N,N0)] containing nitrogen bidentate amine–imine and di-imine ligands derived from glucose. Some chemical properties were discussed. The X-ray molecular structure of [PtCl2(a-D-glucopyranoside-methyl-6-deoxy-6(2-(methylimino)methyl)pyridine) (D) was reported. [Pt Cl2(b-D-glucopyranosylimine-N-(2-pyridinylmethyl))] (A), which is well-soluble both in organic solvents and in water, was tested for cytotoxicity.File in questo prodotto:
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