ABSTRACT: The meso-tetranaphthylporphyrins (TNP) derivatives, 5-(2-hydroxy-1-naphthaldehyde- 4-naphthyleneimine)-10,15,20-trinaphthylporphyrin 3, 5-(salicylidene-4-naphthyleneamine)-10,15,20- trinaphthylporphyrin 4 and 5-(thiophene-2-carboxaldehyde-4-naphthyleneimine)-10,15,20-trinaphthyl- porphyrin 5, were synthesized by the reaction of 5-(4-aminonaphthyl)-l0,15,20-trinaphthylporphyrin 2 with different aldehydes. Their photodynamic activity against K562 cells were evaluated in vitro. They displayed low levels or no dark toxicity and high phototoxicity to K562 cells, especially for 5, which offers potential application in photodynamic therapy.
Synthesis and photodynamic activity of new meso-tetranaphthylporphyrins derivatives
DEL SOLE, Roberta;VASAPOLLO, Giuseppe
2010-01-01
Abstract
ABSTRACT: The meso-tetranaphthylporphyrins (TNP) derivatives, 5-(2-hydroxy-1-naphthaldehyde- 4-naphthyleneimine)-10,15,20-trinaphthylporphyrin 3, 5-(salicylidene-4-naphthyleneamine)-10,15,20- trinaphthylporphyrin 4 and 5-(thiophene-2-carboxaldehyde-4-naphthyleneimine)-10,15,20-trinaphthyl- porphyrin 5, were synthesized by the reaction of 5-(4-aminonaphthyl)-l0,15,20-trinaphthylporphyrin 2 with different aldehydes. Their photodynamic activity against K562 cells were evaluated in vitro. They displayed low levels or no dark toxicity and high phototoxicity to K562 cells, especially for 5, which offers potential application in photodynamic therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
