Gastrointestinal damage (GD) is commonly associated with the inhibition of cyclooxygenase (COX)-1, one of the two known COXs, by traditional non-steroidal anti-inflammatory drugs. More recent evidences have proven that GD is caused by the simultaneous inhibition of the two COXs. This study was designed to evaluate the effect of the selective COX-1 inhibition on gastric integrity.
Selective cyclooxygenase-1 inhibition by p6 and gastrotoxicity: preliminary investigation
LOFRUMENTO, Dario DomenicoCo-primo
Membro del Collaboration Group
;DE NUCCIO, FRANCESCO;LA PESA, VELIA;
2015-01-01
Abstract
Gastrointestinal damage (GD) is commonly associated with the inhibition of cyclooxygenase (COX)-1, one of the two known COXs, by traditional non-steroidal anti-inflammatory drugs. More recent evidences have proven that GD is caused by the simultaneous inhibition of the two COXs. This study was designed to evaluate the effect of the selective COX-1 inhibition on gastric integrity.File in questo prodotto:
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