Large bone or osteochondral defects still need new approaches to ameliorate the regeneration process. The integration of magnetic nanoparticles into synthetic/natural scaffold formulations, could lead to obtain a suitable, responsive “on demand” tool able to guide the regeneration process. The aim of this work was the design and characterization of chitosan-based scaffolds containing dextran-grafted maghemite (DM) with modular mechano-structural and biomimetic properties implemented by the presence of a bioactive agent such the L-arginine amino acid. Both components can act as modulators of the scaffold features and, at the same time, the simultaneous presence of MNPs and L-Arg can be exploited to induce variations with respect to the cytocompatibility responses.
Chitosan-based scaffolds exhibit modular features induced by magnetic nanoparticles and L-arginine amino acid
BARCA, AMILCARE;PALAZZO, BARBARA;SCALERA, FRANCESCA;VERRI, Tiziano;SANNINO, Alessandro;GERVASO, FRANCESCA
2016-01-01
Abstract
Large bone or osteochondral defects still need new approaches to ameliorate the regeneration process. The integration of magnetic nanoparticles into synthetic/natural scaffold formulations, could lead to obtain a suitable, responsive “on demand” tool able to guide the regeneration process. The aim of this work was the design and characterization of chitosan-based scaffolds containing dextran-grafted maghemite (DM) with modular mechano-structural and biomimetic properties implemented by the presence of a bioactive agent such the L-arginine amino acid. Both components can act as modulators of the scaffold features and, at the same time, the simultaneous presence of MNPs and L-Arg can be exploited to induce variations with respect to the cytocompatibility responses.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
