Olfactory impairment is present in up to 90% of patients with Alzheimer's disease (AD) and is present in certain cases of mild cognitive impairment (MCI), a transient phase between normal aging and dementia. Subjects affected by MCI have a higher risk of developing dementia compared to the general population, and studies have found that olfactory deficits could be an indicator of whether such a conversion might happen. Following these assumptions, aim of this study was to investigate olfactory perception in MCI geriatric patients and in OSAs patients. In both clinical sample an alteration of Olfactory Event Related Potentials was found, in particular in the N1 sensorial component. In both groups we also find compensation in the slow perceptive / cognitive response, particularly in the Late Positive Components. These results lead us to think that olfactory processes, as they are linked to subcortical, metabolic and oxidative aspects, can be important biomarkers in the early stages of cognitive impairment.
Potential Role of Olfactory Event Related Potentials as early marker in Mild Cognitive Impairment and in other Neurodegenerative Processes
Sara Invitto
2019-01-01
Abstract
Olfactory impairment is present in up to 90% of patients with Alzheimer's disease (AD) and is present in certain cases of mild cognitive impairment (MCI), a transient phase between normal aging and dementia. Subjects affected by MCI have a higher risk of developing dementia compared to the general population, and studies have found that olfactory deficits could be an indicator of whether such a conversion might happen. Following these assumptions, aim of this study was to investigate olfactory perception in MCI geriatric patients and in OSAs patients. In both clinical sample an alteration of Olfactory Event Related Potentials was found, in particular in the N1 sensorial component. In both groups we also find compensation in the slow perceptive / cognitive response, particularly in the Late Positive Components. These results lead us to think that olfactory processes, as they are linked to subcortical, metabolic and oxidative aspects, can be important biomarkers in the early stages of cognitive impairment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
