The relevant adsorption of cis-[Pt(NH3)2(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity.
Adsorption of the cis-[Pt(NH3)2(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues
BENEDETTI, MICHELE
Primo
;DE CASTRO, FEDERICASecondo
;ROMANO, ALESSANDRO;MIGONI, DANILO;PICCINNI, BARBARA;VERRI, Tiziano;FANIZZI, Francesco Paolo
Ultimo
2016-01-01
Abstract
The relevant adsorption of cis-[Pt(NH3)2(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity.File in questo prodotto:
File | Dimensione | Formato | |
---|---|---|---|
Hy-PhosPt+Figures-rev.pdf
accesso aperto
Tipologia:
Post-print referato (Refereed author’s manuscript)
Licenza:
Creative commons
Dimensione
819.55 kB
Formato
Adobe PDF
|
819.55 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.